OncoDB.HCC Expression View

Gene name : S100P
Ensembl ID ENSG00000163993
Description Protein S100-P (S100 calcium-binding protein P). [Source:Uniprot/SWISSPROT;Acc:P25815]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
69 percent with 2 folds change ( 31 up and 8 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 4 from 1745697 bp to 11749797 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 135221 -- IMAGE clone locate on exon ( tblastx )
510116 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.77) HK1 (-0.10) HK3 (0.16) HK4 (1.34) HK5 (0.74) HK7 (0.33) HK9 (4.37) HK11 (5.39) HK12 (4.00) HK13 (2.32) HK14 (1.93) HK15 (-0.85) HK16 (1.91) HK18 (4.08) HK19 (1.78) HK20 (-1.86) HK21 (-0.40) HK22 (4.87) HK24 (3.81) HK27 (6.06) HK28 (-0.43) HK29 (1.32) HK31 (-0.01) HK33 (1.11) HK36 (-0.47) HK37 (5.06) HK38 (5.52) HK39 (5.09) HK42 (-0.52) HK46 (1.50) HK47 (-1.21) HK49 (0.01) HK62 (0.89) HK63 (2.16) HK64 (-2.14) HK67 (2.61) HK84 (0.00) HK85 (0.23) SF1 (5.66) SF12 (7.99) SF15 (-1.21) SF17 (-1.87) SF18 (6.76) SF21 (5.90) SF22 (-2.97) SF23 (-0.33) SF32 (4.59) SF34 (-0.53) SF35 (4.82) SF3 (4.30) SF30 (1.30) HK2 (-1.32) HK23 (2.56) HK41 (-0.46) SF4 (2.41) SF8 (-0.17) SF9 (3.09)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).