OncoDB.HCC Expression View

Gene name : MAD2L1
Ensembl ID ENSG00000164109
Description Mitotic spindle assembly checkpoint protein MAD2A (MAD2-like 1) (HsMAD2). [Source:Uniprot/SWISSPROT;Acc:Q13257]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
55 percent with 2 folds change ( 29 up and 2 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 4 from 116200029 bp to 126207411 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 814701 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.77) HK1 (-1.28) HK3 (2.61) HK4 (0.81) HK5 (0.83) HK7 (1.13) HK9 (3.13) HK11 (1.16) HK12 (0.46) HK13 (1.25) HK14 (2.06) HK15 (-0.81) HK16 (0.64) HK18 (0.57) HK19 (1.61) HK20 (0.78) HK21 (1.68) HK22 (0.10) HK24 (0.96) HK27 (3.59) HK28 (0.19) HK29 (2.10) HK31 (0.82) HK33 (0.05) HK36 (2.93) HK37 (-0.16) HK38 (0.13) HK39 (2.75) HK42 (0.97) HK46 (1.64) HK47 (0.41) HK49 (1.31) HK62 (1.12) HK63 (2.92) HK64 (-0.34) HK67 (0.09) HK84 (2.28) HK85 (2.62) SF1 (1.27) SF12 (3.84) SF15 (-0.84) SF17 (0.47) SF18 (3.91) SF21 (1.25) SF22 (4.66) SF23 (0.13) SF32 (0.22) SF34 (0.00) SF35 (1.58) SF3 (2.17) SF30 (2.61) HK2 (0.60) HK23 (-1.56) HK41 (1.10) SF4 (0.84) SF8 (0.31) SF9 (1.59)