OncoDB.HCC Expression View

Gene name : CASP3
Ensembl ID ENSG00000164305
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]. [Source:Uniprot/SWISSPROT;Acc:P42574]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
3 percent with 2 folds change ( 2 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- IHC, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 4 from 180785845 bp to 190807623 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 30170 -- IMAGE clone locate on exon ( blastn )
429574 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.72) HK1 (0.47) HK3 (1.18) HK4 (0.05) HK5 (-0.35) HK7 (0.88) HK9 (0.40) HK11 (1.04) HK12 (0.18) HK13 (-0.16) HK14 (0.66) HK15 (-0.37) HK16 (0.10) HK18 (0.37) HK19 (-0.20) HK20 (0.29) HK21 (0.53) HK22 (0.47) HK24 (0.06) HK27 (-0.28) HK28 (0.00) HK29 (-0.55) HK31 (0.99) HK33 (-0.16) HK36 (0.24) HK37 (-0.33) HK38 (-0.05) HK39 (0.74) HK42 (-0.01) HK46 (0.38) HK47 (0.76) HK49 (0.07) HK62 (0.49) HK63 (0.84) HK64 (0.36) HK67 (0.14) HK84 (0.33) HK85 (0.87) SF1 (0.60) SF12 (-0.02) SF15 (0.74) SF17 (-0.32) SF18 (0.33) SF21 (-0.37) SF22 (-0.46) SF23 (0.04) SF32 (-0.03) SF34 (-0.18) SF35 (0.07) SF3 (0.22) SF30 (0.33) HK2 (0.97) HK23 (0.12) HK41 (0.41) SF4 (0.45) SF8 (-0.00) SF9 (-0.13)