OncoDB.HCC Expression View

Gene name : PTTG2
Ensembl ID ENSG00000164611
Description Securin (Pituitary tumor-transforming protein 1) (Tumor-transforming protein 1) (Esp1-associated protein) (hPTTG). [Source:Uniprot/SWISSPROT;Acc:O95997]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
83 percent with 2 folds change ( 40 up and 6 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, ISH, QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 5 from 154781418 bp to 164788323 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 781089 -- IMAGE clone locate on exon ( tblastx )
CH2 (-5.58) HK1 (-0.34) HK3 (2.43) HK4 (1.18) HK5 (1.87) HK7 (2.09) HK9 (3.23) HK11 (2.80) HK12 (0.82) HK13 (1.27) HK14 (3.17) HK15 (1.53) HK16 (1.74) HK18 (1.32) HK19 (1.08) HK20 (2.08) HK21 (1.58) HK22 (4.33) HK24 (1.91) HK27 (4.64) HK28 (0.38) HK29 (4.69) HK31 (2.83) HK33 (3.41) HK36 (0.24) HK37 (2.94) HK38 (4.03) HK39 (3.81) HK42 (3.73) HK46 (1.27) HK47 (2.78) HK49 (0.00) HK62 (3.88) HK63 (3.99) HK64 (1.45) HK67 (1.41) HK84 (0.85) HK85 (-4.14) SF1 (1.19) SF12 (5.04) SF15 (-0.14) SF17 (3.60) SF18 (0.00) SF21 (-7.94) SF22 (-6.09) SF23 (0.32) SF32 (1.99) SF34 (-6.67) SF35 (-6.17) SF3 (7.65) SF30 (3.34) HK2 (-0.05) HK23 (1.79) HK41 (3.77) SF4 (0.87) SF8 (1.90) SF9 (1.86)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).