OncoDB.HCC Expression View

Gene name : FBXL21
Ensembl ID ENSG00000164616
Description F-box and leucine-rich repeat protein 21 [Source:RefSeq_peptide;Acc:NP_036291]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
69 percent with 2 folds change ( 2 up and 30 down in 46 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 5 from 130293991 bp to 140315179 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 433544 -- IMAGE clone locate on exon ( tblastx )
CH2 (-4.38) HK1 (-1.25) HK3 (-1.33) HK4 (-3.09) HK5 (-1.97) HK7 (0.00) HK9 (-2.10) HK11 (-1.34) HK12 (0.00) HK13 (-2.43) HK14 (-5.65) HK15 (-4.97) HK16 (-0.51) HK18 (0.00) HK19 (0.41) HK20 (1.68) HK21 (-2.55) HK22 (-0.30) HK24 (0.88) HK27 (-4.25) HK28 (-2.12) HK29 (-1.33) HK31 (-2.00) HK33 (-1.89) HK36 (1.36) HK37 (-4.79) HK38 (-5.53) HK39 (0.00) HK42 (0.00) HK46 (-0.45) HK47 (0.00) HK49 (-1.74) HK62 (-2.11) HK63 (-0.69) HK64 (-0.94) HK67 (-1.53) HK84 (0.00) HK85 (-2.82) SF1 (-2.91) SF12 (-5.64) SF15 (-4.88) SF17 (-0.04) SF18 (-3.52) SF21 (-1.59) SF22 (0.00) SF23 (0.45) SF32 (-4.72) SF34 (0.00) SF35 (0.00) SF3 (-3.28) SF30 (0.00) HK2 (0.30) HK23 (-0.38) HK41 (0.32) SF4 (0.41) SF8 (-0.72) SF9 (-4.13)