OncoDB.HCC Expression View

Gene name : CTSB
Ensembl ID ENSG00000164733
Description Cathepsin B precursor (EC 3.4.22.1) (Cathepsin B1) (APP secretase) (APPS) [Contains: Cathepsin B light chain; Cathepsin B heavy chain]. [Source:Uniprot/SWISSPROT;Acc:P07858]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
25 percent with 2 folds change ( 9 up and 5 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 8 from 6737442 bp to 16763147 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 898035 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.52) HK1 (-0.04) HK3 (0.07) HK4 (1.82) HK5 (-0.27) HK7 (-0.99) HK9 (-1.21) HK11 (0.24) HK12 (-0.02) HK13 (1.61) HK14 (1.89) HK15 (0.43) HK16 (0.33) HK18 (1.47) HK19 (1.52) HK20 (-0.57) HK21 (0.00) HK22 (-0.05) HK24 (-0.84) HK27 (0.36) HK28 (-0.38) HK29 (-0.59) HK31 (-0.34) HK33 (-0.97) HK36 (0.28) HK37 (0.50) HK38 (-0.28) HK39 (0.71) HK42 (-0.06) HK46 (0.82) HK47 (1.68) HK49 (-0.61) HK62 (-0.88) HK63 (-2.02) HK64 (-0.28) HK67 (-0.11) HK84 (1.64) HK85 (-0.48) SF1 (-0.30) SF12 (-0.40) SF15 (1.72) SF17 (-1.64) SF18 (-1.13) SF21 (-0.84) SF22 (-2.15) SF23 (-0.57) SF32 (-0.43) SF34 (0.00) SF35 (0.54) SF3 (1.34) SF30 (0.52) HK2 (-0.93) HK23 (-0.51) HK41 (0.89) SF4 (-0.82) SF8 (-0.96) SF9 (0.71)