OncoDB.HCC Expression View

Gene name : ALDH1A1
Ensembl ID ENSG00000165092
Description Retinal dehydrogenase 1 (EC 1.2.1.36) (RalDH1) (RALDH 1) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (ALHDII) (ALDH-E1). [Source:Uniprot/SWISSPROT;Acc:P00352]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
48 percent with 2 folds change ( 17 up and 10 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 9 from 69705408 bp to 79757792 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 855624 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.99) HK1 (0.51) HK3 (2.69) HK4 (2.53) HK5 (-0.38) HK7 (1.62) HK9 (-0.52) HK11 (0.79) HK12 (-1.06) HK13 (1.48) HK14 (0.14) HK15 (0.54) HK16 (0.42) HK18 (1.50) HK19 (0.97) HK20 (0.53) HK21 (-1.19) HK22 (0.19) HK24 (2.50) HK27 (1.11) HK28 (1.22) HK29 (0.54) HK31 (1.69) HK33 (1.43) HK36 (0.87) HK37 (2.10) HK38 (-1.48) HK39 (-0.11) HK42 (-0.41) HK46 (2.20) HK47 (1.81) HK49 (-0.06) HK62 (-1.08) HK63 (-1.99) HK64 (2.02) HK67 (0.61) HK84 (1.67) HK85 (-1.76) SF1 (0.94) SF12 (0.20) SF15 (-1.05) SF17 (0.82) SF18 (-1.52) SF21 (0.00) SF22 (-1.16) SF23 (0.94) SF32 (-0.42) SF34 (-0.80) SF35 (0.69) SF3 (0.52) SF30 (-0.82) HK2 (-0.56) HK23 (1.37) HK41 (2.23) SF4 (-2.07) SF8 (0.32) SF9 (-0.83)