OncoDB.HCC Expression View

Gene name : FBP1
Ensembl ID ENSG00000165140
Description Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11) (D-fructose-1,6- bisphosphate 1-phosphohydrolase 1) (FBPase 1). [Source:Uniprot/SWISSPROT;Acc:P09467]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
57 percent with 2 folds change ( 13 up and 20 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 9 from 91405244 bp to 101441686 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 433253 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.09) HK1 (-0.02) HK3 (-3.29) HK4 (-2.66) HK5 (1.21) HK7 (0.02) HK9 (2.45) HK11 (0.15) HK12 (-1.76) HK13 (0.76) HK14 (-1.38) HK15 (-2.82) HK16 (0.06) HK18 (-0.27) HK19 (-0.80) HK20 (-2.08) HK21 (-1.21) HK22 (1.21) HK24 (0.45) HK27 (-0.84) HK28 (-0.29) HK29 (0.06) HK31 (-0.17) HK33 (0.61) HK36 (1.04) HK37 (-0.61) HK38 (-0.41) HK39 (0.61) HK42 (1.09) HK46 (-3.38) HK47 (-2.68) HK49 (-1.42) HK62 (1.13) HK63 (-0.41) HK64 (-1.74) HK67 (0.71) HK84 (-1.79) HK85 (1.86) SF1 (0.71) SF12 (-2.95) SF15 (-2.26) SF17 (1.37) SF18 (1.46) SF21 (0.52) SF22 (3.41) SF23 (-3.52) SF32 (3.68) SF34 (2.43) SF35 (-0.84) SF3 (-0.23) SF30 (-2.83) HK2 (-2.79) HK23 (-2.56) HK41 (2.62) SF4 (-1.63) SF8 (-0.28) SF9 (-4.23)