OncoDB.HCC Expression View

Gene name : GJB2
Ensembl ID ENSG00000165474
Description Gap junction beta-2 protein (Connexin-26) (Cx26). [Source:Uniprot/SWISSPROT;Acc:P29033]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
34 percent with 2 folds change ( 5 up and 12 down in 49 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 13 from 14659609 bp to 24665037 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 823859 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.15) HK1 (-0.52) HK3 (-0.52) HK4 (-2.23) HK5 (0.00) HK7 (0.35) HK9 (0.00) HK11 (0.38) HK12 (-0.47) HK13 (-1.36) HK14 (-0.91) HK15 (-0.50) HK16 (0.20) HK18 (-0.23) HK19 (-0.13) HK20 (1.11) HK21 (-2.01) HK22 (0.12) HK24 (-1.25) HK27 (-0.92) HK28 (-0.72) HK29 (-0.69) HK31 (0.00) HK33 (-0.15) HK36 (-2.66) HK37 (-0.91) HK38 (-0.81) HK39 (-1.57) HK42 (0.84) HK46 (-0.20) HK47 (0.00) HK49 (-0.92) HK62 (-1.31) HK63 (0.31) HK64 (-0.38) HK67 (0.90) HK84 (0.00) HK85 (1.63) SF1 (1.72) SF12 (0.00) SF15 (-1.21) SF17 (0.53) SF18 (0.00) SF21 (2.78) SF22 (0.00) SF23 (-1.23) SF32 (-0.24) SF34 (0.96) SF35 (-1.64) SF3 (-2.50) SF30 (-0.94) HK2 (0.59) HK23 (-0.88) HK41 (0.22) SF4 (-0.17) SF8 (-0.72) SF9 (-2.73)