OncoDB.HCC Expression View

Gene name : NNMT
Ensembl ID ENSG00000166741
Description Nicotinamide N-methyltransferase (EC 2.1.1.1). [Source:Uniprot/SWISSPROT;Acc:P40261]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
73 percent with 2 folds change ( 2 up and 40 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 11 from 108633763 bp to 118688448 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 85840 -- IMAGE clone locate on exon ( tblastx )
CH2 (-6.73) HK1 (-0.77) HK3 (-2.72) HK4 (-1.88) HK5 (-1.15) HK7 (-2.01) HK9 (-6.24) HK11 (-1.88) HK12 (-2.70) HK13 (-0.77) HK14 (-2.34) HK15 (-2.47) HK16 (-0.69) HK18 (-0.36) HK19 (-2.41) HK20 (-2.50) HK21 (-0.96) HK22 (1.59) HK24 (-0.41) HK27 (-1.21) HK28 (0.12) HK29 (-1.51) HK31 (-1.76) HK33 (-1.91) HK36 (0.34) HK37 (-3.50) HK38 (1.91) HK39 (-1.51) HK42 (-3.27) HK46 (-2.71) HK47 (-3.77) HK49 (-1.14) HK62 (-2.02) HK63 (-4.08) HK64 (-6.23) HK67 (-5.35) HK84 (-1.98) HK85 (-0.65) SF1 (-0.36) SF12 (-4.15) SF15 (0.15) SF17 (-1.62) SF18 (-2.08) SF21 (-1.39) SF22 (0.27) SF23 (-0.53) SF32 (-1.29) SF34 (-2.83) SF35 (-2.35) SF3 (-0.94) SF30 (-1.94) HK2 (-6.53) HK23 (-3.21) HK41 (-3.37) SF4 (-1.27) SF8 (-0.56) SF9 (-4.35)