OncoDB.HCC Expression View

Gene name : KIAA0101
Ensembl ID ENSG00000166803
Description PCNA-associated factor (p15PAF) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (HCV NS5A-transactivated protein 9) (L5). [Source:Uniprot/SWISSPROT;Acc:Q15004]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
78 percent with 2 folds change ( 30 up and 13 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 15 from 57444266 bp to 67460755 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 342640 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-8.89) HK3 (3.25) HK4 (1.00) HK5 (1.45) HK7 (0.00) HK9 (3.00) HK11 (-8.15) HK12 (1.19) HK13 (1.66) HK14 (3.76) HK15 (-0.73) HK16 (1.34) HK18 (-4.71) HK19 (2.16) HK20 (2.43) HK21 (2.51) HK22 (-7.81) HK24 (-7.34) HK27 (4.02) HK28 (-1.94) HK29 (3.16) HK31 (1.16) HK33 (1.28) HK36 (-8.50) HK37 (1.95) HK38 (2.03) HK39 (2.58) HK42 (3.93) HK46 (1.68) HK47 (-0.05) HK49 (1.33) HK62 (2.42) HK63 (3.62) HK64 (0.69) HK67 (0.65) HK84 (0.00) HK85 (-4.15) SF1 (2.44) SF12 (-2.81) SF15 (1.05) SF17 (1.45) SF18 (0.80) SF21 (-8.23) SF22 (-5.60) SF23 (-0.36) SF32 (0.81) SF34 (-6.73) SF35 (5.95) SF3 (-7.20) SF30 (4.58) HK2 (-0.97) HK23 (0.12) HK41 (2.60) SF4 (1.26) SF8 (0.49) SF9 (2.85)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).