OncoDB.HCC Expression View

Gene name : PLK1
Ensembl ID ENSG00000166851
Description Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13). [Source:Uniprot/SWISSPROT;Acc:P53350]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
81 percent with 2 folds change ( 27 up and 16 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- ISH    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 16 from 18597692 bp to 28609188 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 744047 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.66) HK3 (2.52) HK4 (1.61) HK5 (0.00) HK7 (2.78) HK9 (3.16) HK11 (-6.64) HK12 (0.35) HK13 (-4.68) HK14 (1.72) HK15 (2.07) HK16 (0.00) HK18 (1.33) HK19 (1.85) HK20 (0.00) HK21 (1.79) HK22 (-7.28) HK24 (2.84) HK27 (4.31) HK28 (-1.87) HK29 (-7.52) HK31 (3.39) HK33 (-3.31) HK36 (1.43) HK37 (1.84) HK38 (-1.13) HK39 (4.45) HK42 (2.17) HK46 (1.49) HK47 (-1.04) HK49 (1.57) HK62 (2.10) HK63 (-6.75) HK64 (2.12) HK67 (0.04) HK84 (0.00) HK85 (-5.30) SF1 (-3.07) SF12 (5.57) SF15 (0.00) SF17 (1.67) SF18 (0.00) SF21 (0.00) SF22 (-4.86) SF23 (-0.45) SF32 (1.49) SF34 (-8.33) SF35 (-4.93) SF3 (0.00) SF30 (4.31) HK2 (-1.51) HK23 (-1.77) HK41 (2.64) SF4 (1.31) SF8 (0.38) SF9 (2.52)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).