OncoDB.HCC Expression View

Gene name : IGF2
Ensembl ID ENSG00000167244
Description Insulin-like growth factor II precursor (IGF-II) (Somatomedin A) [Contains: Insulin-like growth factor II Ala-25 Del]. [Source:Uniprot/SWISSPROT;Acc:P01344]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
80 percent with 2 folds change ( 15 up and 30 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up/down     Method -- ISH, QPCR, RT-PCR, IHC, SSCP, alter promoter    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 11 from 0 bp to 7125616 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 296448 -- IMAGE clone locate on exon ( tblastx )
CH2 (4.66) HK1 (-2.07) HK3 (-0.59) HK4 (-4.62) HK5 (-1.21) HK7 (-2.11) HK9 (-3.84) HK11 (0.00) HK12 (2.69) HK13 (1.81) HK14 (-4.55) HK15 (-3.27) HK16 (-0.47) HK18 (-6.70) HK19 (2.96) HK20 (3.45) HK21 (-0.91) HK22 (0.80) HK24 (-3.95) HK27 (-4.36) HK28 (-1.21) HK29 (3.60) HK31 (-4.69) HK33 (-1.80) HK36 (-1.33) HK37 (-5.08) HK38 (-5.98) HK39 (-5.09) HK42 (-3.72) HK46 (-1.39) HK47 (3.12) HK49 (-0.99) HK62 (-1.55) HK63 (4.75) HK64 (-6.71) HK67 (4.22) HK84 (0.00) HK85 (5.77) SF1 (-0.01) SF12 (-3.24) SF15 (-3.67) SF17 (1.31) SF18 (-4.57) SF21 (-0.29) SF22 (-1.67) SF23 (-1.40) SF32 (-0.94) SF34 (5.15) SF35 (-1.96) SF3 (4.46) SF30 (-3.26) HK2 (3.39) HK23 (4.34) HK41 (-6.64) SF4 (-0.71) SF8 (-0.66) SF9 (-5.16)