OncoDB.HCC Expression View

Gene name : RRM1
Ensembl ID ENSG00000167325
Description Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain). [Source:Uniprot/SWISSPROT;Acc:P23921]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
49 percent with 2 folds change ( 28 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 11 from 0 bp to 9116681 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 856489 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.16) HK1 (0.65) HK3 (1.04) HK4 (0.74) HK5 (1.47) HK7 (0.91) HK9 (1.15) HK11 (1.43) HK12 (0.36) HK13 (1.66) HK14 (2.40) HK15 (-0.17) HK16 (0.16) HK18 (-0.46) HK19 (1.11) HK20 (1.74) HK21 (1.36) HK22 (1.20) HK24 (0.79) HK27 (1.53) HK28 (0.92) HK29 (0.86) HK31 (1.28) HK33 (0.82) HK36 (-0.54) HK37 (0.35) HK38 (0.49) HK39 (1.31) HK42 (1.75) HK46 (0.84) HK47 (1.74) HK49 (1.68) HK62 (1.04) HK63 (0.99) HK64 (0.24) HK67 (0.91) HK84 (1.74) HK85 (0.39) SF1 (0.98) SF12 (1.07) SF15 (0.30) SF17 (0.56) SF18 (0.29) SF21 (-0.58) SF22 (1.80) SF23 (-0.21) SF32 (1.47) SF34 (1.87) SF35 (2.10) SF3 (1.05) SF30 (1.97) HK2 (0.81) HK23 (-0.16) HK41 (1.20) SF4 (0.09) SF8 (0.59) SF9 (1.08)