OncoDB.HCC Expression View

Gene name : SPINT2
Ensembl ID ENSG00000167642
Description Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin). [Source:Uniprot/SWISSPROT;Acc:O43291]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
74 percent with 2 folds change ( 9 up and 31 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene    
Display nearby genome region Chr 19 from 38447007 bp to 48474927 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 470385 -- IMAGE clone locate on exon ( tblastx )
814378 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.83) HK1 (-1.06) HK3 (1.67) HK4 (-2.25) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (2.52) HK12 (-1.51) HK13 (-1.94) HK14 (-1.34) HK15 (0.65) HK16 (-0.83) HK18 (0.43) HK19 (0.84) HK20 (-1.97) HK21 (2.29) HK22 (-1.63) HK24 (-0.25) HK27 (-1.48) HK28 (-1.57) HK29 (-1.02) HK31 (-1.21) HK33 (2.19) HK36 (-2.27) HK37 (-0.98) HK38 (-2.01) HK39 (-0.09) HK42 (-1.50) HK46 (-1.88) HK47 (0.89) HK49 (1.15) HK62 (-0.58) HK63 (-0.79) HK64 (-0.22) HK67 (-1.69) HK84 (-2.34) HK85 (-3.28) SF1 (-1.86) SF12 (-1.47) SF15 (-3.67) SF17 (-3.44) SF18 (1.09) SF21 (1.71) SF22 (1.41) SF23 (-3.42) SF32 (-1.97) SF34 (-1.14) SF35 (1.37) SF3 (-2.11) SF30 (-1.45) HK2 (-2.62) HK23 (-0.75) HK41 (-3.22) SF4 (0.31) SF8 (-1.21) SF9 (-0.34)