OncoDB.HCC Expression View

Gene name : FEN1
Ensembl ID ENSG00000168496
Description Flap endonuclease 1 (EC 3.1.-.-) (Flap structure-specific endonuclease 1) (FEN-1) (Maturation factor 1) (MF1) (hFEN-1) (DNase IV). [Source:Uniprot/SWISSPROT;Acc:P39748]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
66 percent with 2 folds change ( 36 up and 2 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 11 from 56316726 bp to 66321284 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 951142 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.05) HK1 (1.64) HK3 (2.62) HK4 (1.44) HK5 (1.32) HK7 (2.63) HK9 (5.23) HK11 (1.29) HK12 (1.32) HK13 (3.08) HK14 (2.57) HK15 (0.44) HK16 (1.24) HK18 (-0.24) HK19 (1.92) HK20 (1.36) HK21 (0.71) HK22 (1.18) HK24 (1.40) HK27 (1.58) HK28 (0.58) HK29 (1.37) HK31 (0.46) HK33 (0.30) HK36 (0.70) HK37 (1.94) HK38 (1.59) HK39 (1.76) HK42 (2.27) HK46 (1.29) HK47 (0.59) HK49 (0.89) HK62 (-0.48) HK63 (1.61) HK64 (1.62) HK67 (0.61) HK84 (2.84) HK85 (2.35) SF1 (0.31) SF12 (2.70) SF15 (0.83) SF17 (1.98) SF18 (1.23) SF21 (0.56) SF22 (3.59) SF23 (-1.18) SF32 (0.19) SF34 (-0.45) SF35 (2.16) SF3 (1.78) SF30 (1.76) HK2 (-1.11) HK23 (0.25) HK41 (1.23) SF4 (0.39) SF8 (0.31) SF9 (1.51)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).