OncoDB.HCC Expression View

Gene name : MAP2K1
Ensembl ID ENSG00000169032
Description Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1). [Source:Uniprot/SWISSPROT;Acc:Q02750]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
21 percent with 2 folds change ( 0 up and 12 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 15 from 59466674 bp to 69570935 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 33826 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.94) HK1 (-0.66) HK3 (-0.14) HK4 (-1.04) HK5 (-1.52) HK7 (-0.18) HK9 (-0.90) HK11 (-0.75) HK12 (0.02) HK13 (-0.99) HK14 (0.05) HK15 (-1.15) HK16 (0.72) HK18 (-0.09) HK19 (0.03) HK20 (-0.30) HK21 (-0.37) HK22 (-0.44) HK24 (-1.27) HK27 (-0.53) HK28 (-0.78) HK29 (-0.83) HK31 (-0.89) HK33 (-1.02) HK36 (-0.80) HK37 (0.07) HK38 (-0.44) HK39 (-0.04) HK42 (0.55) HK46 (-1.38) HK47 (-0.88) HK49 (-1.15) HK62 (0.07) HK63 (0.47) HK64 (0.23) HK67 (-1.36) HK84 (-0.01) HK85 (-1.20) SF1 (0.10) SF12 (0.46) SF15 (0.27) SF17 (-0.03) SF18 (-2.23) SF21 (-0.35) SF22 (0.16) SF23 (0.34) SF32 (-0.94) SF34 (-0.55) SF35 (-0.98) SF3 (-0.24) SF30 (-0.76) HK2 (-1.81) HK23 (0.00) HK41 (-0.72) SF4 (-0.42) SF8 (-0.78) SF9 (-1.47)