OncoDB.HCC Expression View

Gene name : PTK2
Ensembl ID ENSG00000169398
Description Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2). [Source:Uniprot/SWISSPROT;Acc:Q05397]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
22 percent with 2 folds change ( 13 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, QPCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 8 from 136737683 bp to 146274826 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 855864 -- IMAGE clone locate on exon ( blastn )
724892 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.61) HK1 (1.29) HK3 (1.02) HK4 (0.98) HK5 (0.79) HK7 (-0.12) HK9 (0.18) HK11 (1.14) HK12 (0.80) HK13 (0.23) HK14 (0.33) HK15 (1.29) HK16 (-0.68) HK18 (1.29) HK19 (0.84) HK20 (0.23) HK21 (0.96) HK22 (-0.01) HK24 (0.89) HK27 (0.53) HK28 (-0.15) HK29 (-0.50) HK31 (0.19) HK33 (0.48) HK36 (0.38) HK37 (0.88) HK38 (0.64) HK39 (0.24) HK42 (0.05) HK46 (0.77) HK47 (2.31) HK49 (0.80) HK62 (-0.14) HK63 (-0.23) HK64 (0.81) HK67 (0.89) HK84 (1.42) HK85 (0.16) SF1 (1.13) SF12 (1.02) SF15 (1.49) SF17 (-0.06) SF18 (1.09) SF21 (0.97) SF22 (-0.11) SF23 (-0.17) SF32 (-0.28) SF34 (-0.03) SF35 (0.88) SF3 (0.67) SF30 (0.36) HK2 (0.45) HK23 (0.82) HK41 (1.17) SF4 (0.34) SF8 (0.24) SF9 (0.91)