OncoDB.HCC Expression View

Gene name : HSPA4
Ensembl ID ENSG00000170606
Description Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2) (HSP70RY). [Source:Uniprot/SWISSPROT;Acc:P34932]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
17 percent with 2 folds change ( 10 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Northern    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 5 from 127415561 bp to 137468608 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 289060 -- IMAGE clone locate on exon ( blastn )
773673 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.09) HK1 (1.80) HK3 (0.44) HK4 (0.03) HK5 (1.46) HK7 (-0.85) HK9 (0.26) HK11 (0.77) HK12 (0.57) HK13 (-0.05) HK14 (0.34) HK15 (0.55) HK16 (0.23) HK18 (1.22) HK19 (0.85) HK20 (-0.32) HK21 (0.04) HK22 (0.65) HK24 (0.89) HK27 (0.95) HK28 (-0.87) HK29 (0.79) HK31 (0.92) HK33 (0.76) HK36 (1.25) HK37 (0.25) HK38 (1.21) HK39 (-0.04) HK42 (-0.45) HK46 (0.40) HK47 (1.60) HK49 (0.48) HK62 (0.10) HK63 (0.39) HK64 (-0.13) HK67 (0.41) HK84 (0.82) HK85 (-0.23) SF1 (0.66) SF12 (0.06) SF15 (0.78) SF17 (0.11) SF18 (0.64) SF21 (0.28) SF22 (0.85) SF23 (-0.13) SF32 (0.57) SF34 (-0.09) SF35 (1.40) SF3 (0.77) SF30 (0.01) HK2 (0.87) HK23 (1.68) HK41 (1.53) SF4 (0.44) SF8 (0.40) SF9 (0.81)