OncoDB.HCC Expression View

Gene name : FGB
Ensembl ID ENSG00000171564
Description Fibrinogen beta chain precursor [Contains: Fibrinopeptide B]. [Source:Uniprot/SWISSPROT;Acc:P02675]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
36 percent with 2 folds change ( 6 up and 15 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
Links Entrez Gene    
Display nearby genome region Chr 4 from 150703596 bp to 160711683 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 84713 -- IMAGE clone locate on exon ( tblastx )
241788 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.28) HK1 (-0.26) HK3 (-2.35) HK4 (0.80) HK5 (-1.08) HK7 (-1.97) HK9 (-0.64) HK11 (-0.34) HK12 (-0.35) HK13 (1.35) HK14 (-2.40) HK15 (-2.19) HK16 (-0.73) HK18 (-0.97) HK19 (-0.68) HK20 (-1.32) HK21 (-0.34) HK22 (1.93) HK24 (-0.08) HK27 (-0.47) HK28 (0.60) HK29 (-0.50) HK31 (-0.25) HK33 (-0.77) HK36 (0.73) HK37 (-0.94) HK38 (1.58) HK39 (-0.66) HK42 (-2.89) HK46 (-1.68) HK47 (-0.47) HK49 (0.73) HK62 (-0.84) HK63 (-0.37) HK64 (-0.53) HK67 (-0.48) HK84 (0.45) HK85 (1.98) SF1 (0.66) SF12 (-1.69) SF15 (1.01) SF17 (-0.29) SF18 (-0.89) SF21 (0.21) SF22 (1.59) SF23 (0.05) SF32 (-1.59) SF34 (0.63) SF35 (-1.51) SF3 (0.02) SF30 (0.58) HK2 (-5.21) HK23 (-2.16) HK41 (-0.10) SF4 (-0.70) SF8 (-1.10) SF9 (-2.07)