OncoDB.HCC Expression View

Gene name : PAH
Ensembl ID ENSG00000171759
Description Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase). [Source:Uniprot/SWISSPROT;Acc:P00439]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
32 percent with 2 folds change ( 1 up and 17 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 12 from 96756234 bp to 106835511 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 461727 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.29) HK1 (-0.86) HK3 (-0.55) HK4 (0.11) HK5 (-0.36) HK7 (-1.60) HK9 (-0.54) HK11 (-1.21) HK12 (-0.72) HK13 (0.12) HK14 (-3.48) HK15 (-1.25) HK16 (-0.73) HK18 (-0.83) HK19 (-0.41) HK20 (-0.55) HK21 (-2.58) HK22 (0.23) HK24 (0.10) HK27 (-3.01) HK28 (-0.59) HK29 (-0.91) HK31 (0.61) HK33 (-0.62) HK36 (0.78) HK37 (-1.17) HK38 (-1.15) HK39 (-5.33) HK42 (-3.00) HK46 (-0.23) HK47 (0.88) HK49 (-1.70) HK62 (-0.03) HK63 (-0.25) HK64 (-1.27) HK67 (-0.12) HK84 (0.00) HK85 (0.27) SF1 (0.59) SF12 (-1.12) SF15 (0.34) SF17 (-0.17) SF18 (-3.77) SF21 (-0.04) SF22 (-0.65) SF23 (0.09) SF32 (-1.19) SF34 (0.77) SF35 (-2.07) SF3 (-0.59) SF30 (-4.53) HK2 (-0.34) HK23 (-0.19) HK41 (0.56) SF4 (0.42) SF8 (-0.72) SF9 (-0.55)