OncoDB.HCC Expression View

Gene name : RRM2
Ensembl ID ENSG00000171848
Description Ribonucleoside-diphosphate reductase M2 subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit) (Ribonucleotide reductase small chain). [Source:Uniprot/SWISSPROT;Acc:P31350]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
75 percent with 2 folds change ( 30 up and 11 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 2 from 5179906 bp to 15188996 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 624627 -- IMAGE clone locate on exon ( tblastx )
CH2 (-7.21) HK1 (9.57) HK3 (2.27) HK4 (3.84) HK5 (1.49) HK7 (2.31) HK9 (3.24) HK11 (2.70) HK12 (-0.19) HK13 (1.50) HK14 (3.67) HK15 (1.69) HK16 (-0.07) HK18 (1.10) HK19 (2.98) HK20 (0.49) HK21 (2.05) HK22 (-9.26) HK24 (1.41) HK27 (3.50) HK28 (-0.05) HK29 (-6.90) HK31 (4.94) HK33 (-6.60) HK36 (0.03) HK37 (2.22) HK38 (-5.79) HK39 (3.03) HK42 (2.73) HK46 (0.59) HK47 (0.61) HK49 (0.00) HK62 (3.38) HK63 (5.94) HK64 (1.94) HK67 (1.19) HK84 (0.00) HK85 (-4.66) SF1 (4.71) SF12 (-3.67) SF15 (0.09) SF17 (3.46) SF18 (0.00) SF21 (2.58) SF22 (-6.42) SF23 (-0.78) SF32 (2.89) SF34 (-7.98) SF35 (-5.71) SF3 (0.00) SF30 (4.12) HK2 (-1.19) HK23 (0.81) HK41 (3.30) SF4 (-0.36) SF8 (0.00) SF9 (1.83)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).