OncoDB.HCC Expression View

Gene name : AGXT
Ensembl ID ENSG00000172482
Description Serine--pyruvate aminotransferase (EC 2.6.1.51) (SPT) (Alanine-- glyoxylate aminotransferase) (EC 2.6.1.44) (AGT). [Source:Uniprot/SWISSPROT;Acc:P21549]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
76 percent with 2 folds change ( 1 up and 42 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
Links Entrez Gene    
Display nearby genome region Chr 2 from 236456835 bp to 242751149 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 247117 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.73) HK1 (-1.38) HK3 (-3.54) HK4 (-7.58) HK5 (-1.47) HK7 (-0.39) HK9 (0.00) HK11 (-3.18) HK12 (-1.63) HK13 (-0.64) HK14 (-3.60) HK15 (-3.15) HK16 (0.09) HK18 (-1.68) HK19 (-1.59) HK20 (-2.40) HK21 (-1.32) HK22 (-0.25) HK24 (-1.99) HK27 (-1.48) HK28 (-1.31) HK29 (0.13) HK31 (-2.42) HK33 (-1.35) HK36 (0.59) HK37 (-3.86) HK38 (-1.27) HK39 (-0.60) HK42 (-3.51) HK46 (-2.13) HK47 (-2.34) HK49 (-2.76) HK62 (-0.04) HK63 (-0.94) HK64 (-3.40) HK67 (-2.82) HK84 (-5.54) HK85 (0.40) SF1 (-3.92) SF12 (-3.76) SF15 (-3.05) SF17 (0.52) SF18 (-3.12) SF21 (1.36) SF22 (0.01) SF23 (-2.96) SF32 (-1.44) SF34 (-1.57) SF35 (-1.72) SF3 (-1.09) SF30 (-1.96) HK2 (-2.00) HK23 (-3.21) HK41 (-0.15) SF4 (-1.81) SF8 (-2.30) SF9 (-3.64)