OncoDB.HCC Expression View

Gene name : HPSE
Ensembl ID ENSG00000173083
Description Heparanase precursor (EC 3.2.-.-) (Heparanase-1) (Hpa1) (Endo- glucoronidase) [Contains: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]. [Source:Uniprot/SWISSPROT;Acc:Q9Y251]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
27 percent with 2 folds change ( 5 up and 4 down in 33 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western, QPCR, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene    
Display nearby genome region Chr 4 from 79432639 bp to 89475329 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 260138 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.22) HK3 (1.43) HK4 (0.00) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (-0.37) HK12 (-0.61) HK13 (-0.42) HK14 (-0.23) HK15 (-0.75) HK16 (0.00) HK18 (0.81) HK19 (0.36) HK20 (0.34) HK21 (0.60) HK22 (-0.34) HK24 (-1.00) HK27 (-0.91) HK28 (-0.47) HK29 (-0.82) HK31 (-0.43) HK33 (-0.93) HK36 (0.00) HK37 (1.08) HK38 (0.00) HK39 (-0.61) HK42 (0.55) HK46 (1.68) HK47 (0.00) HK49 (0.00) HK62 (0.00) HK63 (-2.15) HK64 (0.00) HK67 (0.00) HK84 (2.20) HK85 (0.00) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (-1.80) SF34 (-1.06) SF35 (0.96) SF3 (0.00) SF30 (-0.22) HK2 (-0.26) HK23 (0.80) HK41 (0.00) SF4 (-0.05) SF8 (0.20) SF9 (2.77)