OncoDB.HCC Expression View

Gene name : SLC22A1
Ensembl ID ENSG00000175003
Description solute carrier family 22 member 1 isoform a [Source:RefSeq_peptide;Acc:NP_003048]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
70 percent with 2 folds change ( 7 up and 27 down in 48 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 6 from 155462795 bp to 165499740 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 436135 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-3.70) HK3 (-3.16) HK4 (-1.49) HK5 (-3.23) HK7 (-0.12) HK9 (0.91) HK11 (-2.15) HK12 (-1.74) HK13 (1.34) HK14 (-7.62) HK15 (-3.79) HK16 (1.08) HK18 (-2.18) HK19 (-4.18) HK20 (0.00) HK21 (-2.23) HK22 (1.53) HK24 (-0.24) HK27 (-3.40) HK28 (-0.41) HK29 (0.34) HK31 (-0.09) HK33 (-0.40) HK36 (0.82) HK37 (-7.47) HK38 (0.85) HK39 (-5.64) HK42 (0.05) HK46 (-8.55) HK47 (0.00) HK49 (0.16) HK62 (1.26) HK63 (-0.45) HK64 (-2.06) HK67 (0.00) HK84 (-1.66) HK85 (-0.05) SF1 (0.00) SF12 (-5.90) SF15 (-3.23) SF17 (-0.49) SF18 (0.00) SF21 (3.93) SF22 (0.00) SF23 (-2.24) SF32 (-5.13) SF34 (2.96) SF35 (0.00) SF3 (-2.03) SF30 (0.00) HK2 (-5.12) HK23 (-3.10) HK41 (1.21) SF4 (-2.78) SF8 (-1.97) SF9 (-5.33)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).