OncoDB.HCC Expression View

Gene name : UBE2C
Ensembl ID ENSG00000175063
Description Ubiquitin-conjugating enzyme E2 C (EC 6.3.2.19) (Ubiquitin-protein ligase C) (Ubiquitin carrier protein C) (UbcH10). [Source:Uniprot/SWISSPROT;Acc:O00762]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
71 percent with 2 folds change ( 30 up and 11 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 20 from 38874662 bp to 48879003 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 769921 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.53) HK3 (2.64) HK4 (2.20) HK5 (0.88) HK7 (2.59) HK9 (3.09) HK11 (-5.44) HK12 (1.64) HK13 (-6.10) HK14 (3.99) HK15 (2.42) HK16 (0.00) HK18 (0.96) HK19 (2.37) HK20 (-1.77) HK21 (1.10) HK22 (-6.68) HK24 (4.23) HK27 (8.97) HK28 (-0.29) HK29 (4.24) HK31 (0.48) HK33 (0.31) HK36 (-7.79) HK37 (2.80) HK38 (4.07) HK39 (3.74) HK42 (3.96) HK46 (2.40) HK47 (1.68) HK49 (1.19) HK62 (1.95) HK63 (2.60) HK64 (2.29) HK67 (1.71) HK84 (4.68) HK85 (-2.92) SF1 (-6.51) SF12 (-2.14) SF15 (0.42) SF17 (0.61) SF18 (0.00) SF21 (-6.49) SF22 (-5.52) SF23 (-0.25) SF32 (-0.11) SF34 (3.96) SF35 (6.28) SF3 (-4.76) SF30 (5.07) HK2 (-0.29) HK23 (1.40) HK41 (3.29) SF4 (0.44) SF8 (-0.43) SF9 (2.36)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).