OncoDB.HCC Expression View

Gene name : A2M
Ensembl ID ENSG00000175899
Description Alpha-2-macroglobulin precursor (Alpha-2-M). [Source:Uniprot/SWISSPROT;Acc:P01023]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
63 percent with 2 folds change ( 4 up and 31 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 12 from 4102453 bp to 14159825 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 878182 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.25) HK1 (-1.77) HK3 (-2.30) HK4 (0.88) HK5 (-3.33) HK7 (-1.74) HK9 (-2.47) HK11 (0.95) HK12 (-1.57) HK13 (0.74) HK14 (-0.94) HK15 (0.41) HK16 (-2.23) HK18 (-2.22) HK19 (0.00) HK20 (-1.70) HK21 (-0.56) HK22 (-0.53) HK24 (-1.86) HK27 (-0.16) HK28 (-2.10) HK29 (-2.09) HK31 (-3.38) HK33 (-0.65) HK36 (0.00) HK37 (-0.40) HK38 (1.25) HK39 (-0.14) HK42 (-2.50) HK46 (-2.63) HK47 (2.43) HK49 (0.20) HK62 (-1.65) HK63 (-1.50) HK64 (-2.22) HK67 (-2.09) HK84 (-1.55) HK85 (0.27) SF1 (-4.20) SF12 (-3.42) SF15 (-0.49) SF17 (-3.33) SF18 (1.70) SF21 (-0.78) SF22 (-0.51) SF23 (-2.36) SF32 (0.61) SF34 (-0.85) SF35 (-2.06) SF3 (-0.52) SF30 (-1.31) HK2 (1.28) HK23 (-1.65) HK41 (-2.06) SF4 (-1.18) SF8 (-2.81) SF9 (-2.66)