OncoDB.HCC Expression View

Gene name : SHMT1
Ensembl ID ENSG00000176974
Description Serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT). [Source:Uniprot/SWISSPROT;Acc:P34896]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
36 percent with 2 folds change ( 1 up and 18 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 17 from 13171920 bp to 23207581 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 39798 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.40) HK1 (-0.46) HK3 (-0.25) HK4 (0.00) HK5 (-0.33) HK7 (0.19) HK9 (-0.57) HK11 (-2.81) HK12 (-1.23) HK13 (0.00) HK14 (0.00) HK15 (0.00) HK16 (-0.78) HK18 (-0.41) HK19 (-0.68) HK20 (-0.21) HK21 (-1.97) HK22 (0.74) HK24 (-0.34) HK27 (-1.65) HK28 (0.10) HK29 (1.01) HK31 (0.57) HK33 (-0.47) HK36 (-0.42) HK37 (-2.78) HK38 (-1.07) HK39 (-0.18) HK42 (-0.82) HK46 (-0.34) HK47 (-3.01) HK49 (-0.71) HK62 (0.44) HK63 (-0.45) HK64 (-1.48) HK67 (-2.24) HK84 (-2.32) HK85 (-0.96) SF1 (-1.22) SF12 (-3.64) SF15 (0.05) SF17 (0.60) SF18 (-3.64) SF21 (-0.70) SF22 (0.38) SF23 (-0.50) SF32 (0.18) SF34 (0.32) SF35 (-1.83) SF3 (-1.04) SF30 (-2.88) HK2 (0.00) HK23 (-0.55) HK41 (-0.01) SF4 (0.29) SF8 (-0.88) SF9 (-3.07)