OncoDB.HCC Expression View

Gene name : CD163
Ensembl ID ENSG00000177575
Description Scavenger receptor cysteine-rich type 1 protein M130 precursor (CD163 antigen) (Hemoglobin scavenger receptor) [Contains: Soluble CD163 (sCD163)]. [Source:Uniprot/SWISSPROT;Acc:Q86VB7]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
61 percent with 2 folds change ( 1 up and 33 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene    
Display nearby genome region Chr 12 from 2515021 bp to 12547553 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 727292 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.66) HK1 (-1.68) HK3 (-1.37) HK4 (-2.57) HK5 (-1.18) HK7 (-2.48) HK9 (0.00) HK11 (-0.88) HK12 (-1.98) HK13 (-0.87) HK14 (-2.85) HK15 (-2.42) HK16 (-0.16) HK18 (0.90) HK19 (-0.50) HK20 (-2.18) HK21 (-1.30) HK22 (-0.23) HK24 (-2.55) HK27 (-0.10) HK28 (-2.28) HK29 (-1.22) HK31 (-0.93) HK33 (0.22) HK36 (-3.78) HK37 (-1.20) HK38 (-1.43) HK39 (-1.79) HK42 (-2.16) HK46 (0.16) HK47 (-1.67) HK49 (-0.60) HK62 (0.65) HK63 (-3.16) HK64 (-3.37) HK67 (-0.71) HK84 (-2.01) HK85 (-2.20) SF1 (1.64) SF12 (-1.39) SF15 (-2.92) SF17 (0.00) SF18 (-0.38) SF21 (-0.58) SF22 (1.00) SF23 (-2.72) SF32 (-1.45) SF34 (-1.36) SF35 (-0.24) SF3 (-1.52) SF30 (0.03) HK2 (-2.53) HK23 (0.44) HK41 (-1.31) SF4 (0.59) SF8 (-1.08) SF9 (0.69)