OncoDB.HCC Expression View

Gene name : AP3S1
Ensembl ID ENSG00000177879
Description AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Source:Uniprot/SWISSPROT;Acc:Q92572]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
15 percent with 2 folds change ( 9 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 5 from 110205239 bp to 120277591 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 796757 -- IMAGE clone locate on exon ( tblastx )
1607112 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.55) HK1 (1.25) HK3 (0.20) HK4 (0.08) HK5 (1.43) HK7 (0.42) HK9 (0.23) HK11 (0.94) HK12 (0.31) HK13 (0.17) HK14 (0.58) HK15 (0.54) HK16 (0.98) HK18 (0.77) HK19 (0.38) HK20 (0.20) HK21 (0.45) HK22 (0.79) HK24 (0.57) HK27 (0.62) HK28 (0.51) HK29 (0.29) HK31 (0.63) HK33 (0.52) HK36 (0.50) HK37 (0.73) HK38 (0.56) HK39 (0.00) HK42 (-0.12) HK46 (-0.14) HK47 (1.58) HK49 (0.82) HK62 (-0.37) HK63 (0.29) HK64 (0.27) HK67 (0.77) HK84 (0.19) HK85 (1.08) SF1 (1.35) SF12 (0.27) SF15 (1.28) SF17 (-0.55) SF18 (-0.57) SF21 (-0.31) SF22 (-0.69) SF23 (-0.07) SF32 (0.39) SF34 (0.81) SF35 (-0.14) SF3 (0.32) SF30 (-0.15) HK2 (1.38) HK23 (1.18) HK41 (1.67) SF4 (0.19) SF8 (-0.00) SF9 (-0.15)