OncoDB.HCC Expression View

Gene name : NPM1
Ensembl ID ENSG00000181163
Description Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38). [Source:Uniprot/SWISSPROT;Acc:P06748]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
43 percent with 2 folds change ( 24 up and 1 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
up     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 5 from 165746725 bp to 175770492 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 884301 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.08) HK1 (1.76) HK3 (1.29) HK4 (1.22) HK5 (0.41) HK7 (-0.87) HK9 (0.72) HK11 (1.68) HK12 (0.09) HK13 (0.94) HK14 (1.41) HK15 (-0.34) HK16 (0.17) HK18 (1.72) HK19 (1.94) HK20 (-0.46) HK21 (1.31) HK22 (1.66) HK24 (0.99) HK27 (2.03) HK28 (0.70) HK29 (-0.67) HK31 (-0.03) HK33 (0.34) HK36 (2.52) HK37 (2.39) HK38 (1.85) HK39 (-0.37) HK42 (0.12) HK46 (0.32) HK47 (3.70) HK49 (0.83) HK62 (-1.53) HK63 (-0.22) HK64 (0.10) HK67 (1.15) HK84 (0.54) HK85 (0.58) SF1 (1.43) SF12 (1.31) SF15 (2.64) SF17 (-0.81) SF18 (0.54) SF21 (-0.90) SF22 (0.18) SF23 (-0.75) SF32 (-0.27) SF34 (-0.80) SF35 (1.11) SF3 (0.52) SF30 (1.22) HK2 (1.40) HK23 (-0.19) HK41 (2.95) SF4 (0.12) SF8 (-0.30) SF9 (2.25)