OncoDB.HCC Expression View

Gene name : SOCS3
Ensembl ID ENSG00000184557
Description Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3). [Source:Uniprot/SWISSPROT;Acc:O14543]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
70 percent with 2 folds change ( 0 up and 40 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 17 from 68864459 bp to 78774742 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 84211 -- IMAGE clone locate on exon ( tblastx )
362278 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.95) HK1 (-0.26) HK3 (-2.71) HK4 (-2.33) HK5 (-1.50) HK7 (-2.41) HK9 (-1.74) HK11 (-0.64) HK12 (-2.53) HK13 (-2.61) HK14 (-1.28) HK15 (-1.20) HK16 (-0.07) HK18 (-1.77) HK19 (-2.86) HK20 (-2.00) HK21 (0.86) HK22 (-1.60) HK24 (-2.98) HK27 (0.13) HK28 (-1.67) HK29 (-2.85) HK31 (-1.96) HK33 (-2.03) HK36 (-0.34) HK37 (-2.65) HK38 (-0.32) HK39 (-1.23) HK42 (-3.27) HK46 (-2.03) HK47 (-3.40) HK49 (-0.75) HK62 (0.03) HK63 (-3.99) HK64 (-3.45) HK67 (-2.34) HK84 (-0.41) HK85 (-2.13) SF1 (-1.82) SF12 (-2.04) SF15 (0.24) SF17 (-2.91) SF18 (-2.55) SF21 (0.05) SF22 (-0.47) SF23 (-1.29) SF32 (-0.28) SF34 (-1.99) SF35 (-1.55) SF3 (-2.14) SF30 (-0.75) HK2 (-4.05) HK23 (0.70) HK41 (-2.26) SF4 (-1.77) SF8 (-0.66) SF9 (-1.54)