OncoDB.HCC Expression View

Gene name : SOCS1
Ensembl ID ENSG00000185338
Description Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3). [Source:Uniprot/SWISSPROT;Acc:O15524]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
62 percent with 2 folds change ( 10 up and 23 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- 2D-PAGE, RT-PCR, Methylation    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene    
Display nearby genome region Chr 16 from 6255775 bp to 16257540 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 712668 -- IMAGE clone locate on exon ( tblastx )
811006 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.14) HK1 (1.72) HK3 (-1.83) HK4 (-0.24) HK5 (1.43) HK7 (-2.60) HK9 (-1.24) HK11 (0.19) HK12 (-0.19) HK13 (-0.25) HK14 (1.51) HK15 (0.41) HK16 (1.78) HK18 (0.24) HK19 (-1.99) HK20 (-1.00) HK21 (-0.05) HK22 (0.01) HK24 (-1.86) HK27 (1.10) HK28 (-2.24) HK29 (-2.87) HK31 (-0.70) HK33 (-2.41) HK36 (-0.68) HK37 (-1.67) HK38 (2.22) HK39 (1.04) HK42 (-2.02) HK46 (2.47) HK47 (0.00) HK49 (0.00) HK62 (-0.81) HK63 (-2.77) HK64 (-1.04) HK67 (0.00) HK84 (0.00) HK85 (-1.28) SF1 (-3.16) SF12 (1.00) SF15 (-0.28) SF17 (-1.84) SF18 (0.95) SF21 (-0.10) SF22 (-1.02) SF23 (0.21) SF32 (-1.25) SF34 (-1.01) SF35 (-2.21) SF3 (-1.95) SF30 (0.56) HK2 (-0.79) HK23 (0.46) HK41 (-2.38) SF4 (-0.00) SF8 (1.38) SF9 (-0.20)