OncoDB.HCC Expression View

Gene name : PTCH1
Ensembl ID ENSG00000185920
Description Protein patched homolog 1 (PTC1) (PTC). [Source:Uniprot/SWISSPROT;Acc:Q13635]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
30 percent with 2 folds change ( 6 up and 10 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- ISH, QPCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 9 from 92245083 bp to 102318923 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 28611 -- IMAGE clone locate on exon ( blastn )
594540 -- IMAGE clone locate on exon ( tblastx )
1473326 -- IMAGE clone locate on exon ( tblastx )
1559366 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.12) HK3 (-1.24) HK4 (0.00) HK5 (-0.02) HK7 (-0.63) HK9 (-0.39) HK11 (-0.31) HK12 (0.21) HK13 (-1.23) HK14 (-0.24) HK15 (-0.63) HK16 (0.48) HK18 (-1.11) HK19 (-0.40) HK20 (-0.58) HK21 (-0.47) HK22 (-0.06) HK24 (-0.03) HK27 (-0.76) HK28 (-0.40) HK29 (0.12) HK31 (1.76) HK33 (1.82) HK36 (0.02) HK37 (-1.75) HK38 (-0.55) HK39 (-0.60) HK42 (2.23) HK46 (-0.23) HK47 (-1.10) HK49 (-0.66) HK62 (0.14) HK63 (-3.72) HK64 (-1.13) HK67 (-0.59) HK84 (-2.20) HK85 (-0.50) SF1 (-1.31) SF12 (0.57) SF15 (-1.08) SF17 (1.31) SF18 (0.84) SF21 (1.68) SF22 (0.00) SF23 (0.51) SF32 (-0.38) SF34 (1.50) SF35 (0.15) SF3 (0.00) SF30 (-0.51) HK2 (0.80) HK23 (-0.28) HK41 (-0.86) SF4 (-0.11) SF8 (-0.63) SF9 (-0.95)