OncoDB.HCC Expression View

Gene name : MT1X
Ensembl ID ENSG00000187193
Description Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX). [Source:Uniprot/SWISSPROT;Acc:P80297]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
83 percent with 2 folds change ( 1 up and 44 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 16 from 50273894 bp to 60275608 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 297392 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.01) HK1 (-1.95) HK3 (-4.75) HK4 (-4.08) HK5 (-3.04) HK7 (-2.96) HK9 (-4.74) HK11 (-4.00) HK12 (-2.95) HK13 (-0.57) HK14 (-2.52) HK15 (-3.80) HK16 (0.27) HK18 (-1.99) HK19 (-3.12) HK20 (-3.15) HK21 (-0.62) HK22 (-0.38) HK24 (-2.61) HK27 (-2.74) HK28 (0.44) HK29 (-0.12) HK31 (-4.40) HK33 (-2.47) HK36 (1.34) HK37 (-5.32) HK38 (-4.45) HK39 (-1.07) HK42 (-3.66) HK46 (-2.48) HK47 (-2.95) HK49 (-3.75) HK62 (-2.19) HK63 (-1.82) HK64 (-5.28) HK67 (-7.63) HK84 (0.00) HK85 (0.25) SF1 (-5.07) SF12 (-4.22) SF15 (-1.98) SF17 (-1.75) SF18 (-3.17) SF21 (0.21) SF22 (-1.12) SF23 (-4.21) SF32 (-2.30) SF34 (-4.12) SF35 (-1.79) SF3 (0.00) SF30 (-7.39) HK2 (-2.27) HK23 (0.00) HK41 (0.21) SF4 (-2.31) SF8 (-3.15) SF9 (-3.77)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).