OncoDB.HCC Expression View

Gene name : COL4A1
Ensembl ID ENSG00000187498
Description Collagen alpha-1(IV) chain precursor. [Source:Uniprot/SWISSPROT;Acc:P02462]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
59 percent with 2 folds change ( 32 up and 2 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 13 from 104599311 bp to 114142980 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 145292 -- IMAGE clone locate on exon ( tblastx )
491692 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.50) HK1 (1.75) HK3 (1.78) HK4 (-0.11) HK5 (3.80) HK7 (0.89) HK9 (0.86) HK11 (2.32) HK12 (0.79) HK13 (1.51) HK14 (1.24) HK15 (1.15) HK16 (2.12) HK18 (0.46) HK19 (1.13) HK20 (0.87) HK21 (2.44) HK22 (1.33) HK24 (2.00) HK27 (1.66) HK28 (0.16) HK29 (-0.18) HK31 (3.00) HK33 (0.09) HK36 (1.92) HK37 (1.57) HK38 (2.62) HK39 (1.46) HK42 (-0.21) HK46 (0.23) HK47 (-0.29) HK49 (1.42) HK62 (1.03) HK63 (-1.34) HK64 (0.90) HK67 (0.56) HK84 (1.46) HK85 (0.21) SF1 (2.01) SF12 (-0.35) SF15 (2.50) SF17 (1.39) SF18 (1.35) SF21 (0.52) SF22 (4.28) SF23 (-1.45) SF32 (1.93) SF34 (0.88) SF35 (1.77) SF3 (-0.05) SF30 (1.31) HK2 (0.80) HK23 (2.21) HK41 (1.57) SF4 (0.76) SF8 (2.60) SF9 (0.79)