OncoDB.HCC Expression View

Gene name : MUTED
Ensembl ID ENSG00000188428
Description Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46). [Source:Uniprot/SWISSPROT;Acc:Q8NBS9]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
8 percent with 2 folds change ( 4 up and 1 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 6 from 2826482 bp to 13009646 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 588561 -- IMAGE clone locate on exon ( tblastx )
731202 -- IMAGE clone locate on exon ( tblastx )
796652 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.27) HK1 (-0.22) HK3 (0.20) HK4 (0.42) HK5 (-0.51) HK7 (0.31) HK9 (0.44) HK11 (-1.07) HK12 (-0.26) HK13 (2.57) HK14 (0.28) HK15 (-0.14) HK16 (0.01) HK18 (0.02) HK19 (-0.84) HK20 (0.78) HK21 (0.10) HK22 (0.39) HK24 (0.26) HK27 (0.70) HK28 (0.22) HK29 (-0.32) HK31 (0.73) HK33 (-0.00) HK36 (0.73) HK37 (0.25) HK38 (0.57) HK39 (-0.43) HK42 (0.24) HK46 (-0.30) HK47 (0.63) HK49 (0.34) HK62 (-0.73) HK63 (1.58) HK64 (-0.04) HK67 (0.19) HK84 (-0.57) HK85 (0.04) SF1 (0.56) SF12 (0.44) SF15 (1.25) SF17 (0.99) SF18 (0.00) SF21 (-0.88) SF22 (0.01) SF23 (-0.24) SF32 (-0.16) SF34 (0.35) SF35 (-0.48) SF3 (0.10) SF30 (0.67) HK2 (0.29) HK23 (-0.16) HK41 (-0.25) SF4 (-0.04) SF8 (-0.17) SF9 (0.09)