OncoDB.HCC Expression View

Gene name : CLDN4
Ensembl ID ENSG00000189143
Description Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE- receptor) (CPE-R) (Williams-Beuren syndrome chromosome region 8 protein). [Source:Uniprot/SWISSPROT;Acc:O14493]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
69 percent with 2 folds change ( 15 up and 23 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene    
Display nearby genome region Chr 7 from 67880010 bp to 77884950 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 346510 -- IMAGE clone locate on exon ( tblastx )
770388 -- IMAGE clone locate on exon ( tblastx )
967930 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.55) HK1 (-1.67) HK3 (0.68) HK4 (-0.48) HK5 (-2.53) HK7 (1.67) HK9 (-1.30) HK11 (2.99) HK12 (0.52) HK13 (-1.26) HK14 (1.36) HK15 (1.32) HK16 (0.56) HK18 (0.06) HK19 (-0.48) HK20 (-2.97) HK21 (2.27) HK22 (0.13) HK24 (0.04) HK27 (1.82) HK28 (-1.23) HK29 (-0.10) HK31 (-1.23) HK33 (-1.12) HK36 (-1.02) HK37 (-1.15) HK38 (-0.59) HK39 (1.55) HK42 (-1.42) HK46 (1.99) HK47 (-0.74) HK49 (0.00) HK62 (1.03) HK63 (-0.78) HK64 (-2.81) HK67 (-2.61) HK84 (-2.28) HK85 (-3.23) SF1 (1.10) SF12 (0.40) SF15 (0.19) SF17 (-2.49) SF18 (1.80) SF21 (1.63) SF22 (0.48) SF23 (-3.26) SF32 (3.83) SF34 (-0.44) SF35 (1.26) SF3 (-2.96) SF30 (-0.93) HK2 (-2.05) HK23 (2.98) HK41 (-1.05) SF4 (-1.36) SF8 (0.00) SF9 (-1.16)