OncoDB.HCC Expression View

Gene name : AKR1C3
Ensembl ID ENSG00000196139
Description Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (3-alpha- hydroxysteroid dehydrogenase type 2) (EC 1.1.1.213) (3-alpha-HSD type 2) (3-alpha-HSD type II, brain) (Prostaglandin F synthase) [Source:Uniprot/SWISSPROT;Acc:P42330]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 26 up and 3 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
Links Entrez Gene    
Display nearby genome region Chr 10 from 125985 bp to 10139878 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1473304 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.30) HK1 (0.56) HK3 (1.86) HK4 (2.62) HK5 (0.26) HK7 (0.86) HK9 (0.50) HK11 (-0.45) HK12 (-0.18) HK13 (0.78) HK14 (1.29) HK15 (0.83) HK16 (-0.50) HK18 (1.05) HK19 (-0.32) HK20 (0.28) HK21 (-1.36) HK22 (-0.14) HK24 (1.57) HK27 (2.03) HK28 (1.80) HK29 (1.07) HK31 (2.38) HK33 (1.24) HK36 (0.57) HK37 (3.26) HK38 (-1.14) HK39 (-0.47) HK42 (0.54) HK46 (2.73) HK47 (2.58) HK49 (-0.27) HK62 (-0.88) HK63 (1.66) HK64 (1.33) HK67 (1.72) HK84 (3.39) HK85 (-0.19) SF1 (1.03) SF12 (1.96) SF15 (0.88) SF17 (-0.38) SF18 (-0.47) SF21 (-1.28) SF22 (2.02) SF23 (0.88) SF32 (-0.50) SF34 (-0.10) SF35 (1.61) SF3 (1.48) SF30 (0.57) HK2 (2.09) HK23 (0.68) HK41 (2.04) SF4 (1.75) SF8 (0.18) SF9 (0.94)