OncoDB.HCC Expression View

Gene name : SIAH1
Ensembl ID ENSG00000196470
Description Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a). [Source:Uniprot/SWISSPROT;Acc:Q8IUQ4]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
21 percent with 2 folds change ( 0 up and 12 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 16 from 41947778 bp to 52039814 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 782594 -- IMAGE clone locate on exon ( tblastx )
813462 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.98) HK1 (-0.84) HK3 (-0.26) HK4 (-0.86) HK5 (0.00) HK7 (0.00) HK9 (-0.44) HK11 (-0.65) HK12 (0.04) HK13 (-0.79) HK14 (-0.54) HK15 (-0.69) HK16 (-0.05) HK18 (-0.46) HK19 (0.30) HK20 (-0.08) HK21 (-0.59) HK22 (0.13) HK24 (-0.53) HK27 (-1.20) HK28 (-0.85) HK29 (-0.26) HK31 (-0.26) HK33 (-0.16) HK36 (-0.52) HK37 (-1.30) HK38 (-1.22) HK39 (-0.20) HK42 (-1.21) HK46 (-0.47) HK47 (-0.57) HK49 (-0.82) HK62 (0.68) HK63 (-0.06) HK64 (-0.19) HK67 (0.19) HK84 (-0.91) HK85 (-0.63) SF1 (-2.17) SF12 (-4.13) SF15 (-0.38) SF17 (-1.40) SF18 (-1.67) SF21 (-1.75) SF22 (-3.62) SF23 (0.77) SF32 (-0.51) SF34 (-0.24) SF35 (-0.26) SF3 (0.31) SF30 (-0.78) HK2 (-0.77) HK23 (-1.21) HK41 (-0.36) SF4 (-0.80) SF8 (-0.69) SF9 (-1.35)