OncoDB.HCC Expression View

Gene name : MME
Ensembl ID ENSG00000196549
Description Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen). [Source:Uniprot/SWISSPROT;Acc:P08473]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
54 percent with 2 folds change ( 5 up and 26 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 3 from 151284651 bp to 161384186 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 200814 -- IMAGE clone locate on exon ( tblastx )
209758 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.23) HK1 (0.41) HK3 (0.14) HK4 (-0.51) HK5 (0.78) HK7 (2.57) HK9 (-1.11) HK11 (-2.74) HK12 (-1.84) HK13 (0.04) HK14 (-2.75) HK15 (-2.96) HK16 (-0.32) HK18 (-1.43) HK19 (-1.43) HK20 (1.75) HK21 (-2.02) HK22 (-0.91) HK24 (-1.12) HK27 (-0.86) HK28 (0.29) HK29 (0.63) HK31 (0.33) HK33 (-2.11) HK36 (0.18) HK37 (-1.90) HK38 (-2.40) HK39 (-0.53) HK42 (-1.09) HK46 (2.43) HK47 (-1.78) HK49 (-1.95) HK62 (-0.75) HK63 (0.14) HK64 (-0.19) HK67 (0.22) HK84 (-0.67) HK85 (0.53) SF1 (-0.31) SF12 (-2.49) SF15 (-2.05) SF17 (0.60) SF18 (-3.19) SF21 (-1.20) SF22 (-2.21) SF23 (0.97) SF32 (0.06) SF34 (-0.20) SF35 (-1.51) SF3 (-1.49) SF30 (-1.58) HK2 (-1.32) HK23 (2.06) HK41 (1.61) SF4 (-0.53) SF8 (-0.05) SF9 (-1.96)