OncoDB.HCC Expression View

Gene name : ADH4
Ensembl ID ENSG00000198099
Description Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain). [Source:Uniprot/SWISSPROT;Acc:P08319]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
67 percent with 2 folds change ( 5 up and 32 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene    
Display nearby genome region Chr 4 from 95263855 bp to 105284472 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 208542 -- IMAGE clone locate on exon ( tblastx )
429323 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.19) HK1 (-0.55) HK3 (-7.88) HK4 (0.42) HK5 (1.11) HK7 (1.38) HK9 (-2.13) HK11 (-2.79) HK12 (-2.31) HK13 (-4.06) HK14 (-5.58) HK15 (-3.11) HK16 (-0.13) HK18 (-1.89) HK19 (-1.20) HK20 (-2.34) HK21 (-2.28) HK22 (1.36) HK24 (-0.22) HK27 (-4.32) HK28 (0.98) HK29 (-0.77) HK31 (-0.01) HK33 (-0.25) HK36 (1.23) HK37 (-4.10) HK38 (-4.48) HK39 (-4.72) HK42 (-2.33) HK46 (-1.17) HK47 (-5.15) HK49 (-2.45) HK62 (0.13) HK63 (-0.38) HK64 (-2.46) HK67 (-1.99) HK84 (0.00) HK85 (-0.19) SF1 (0.85) SF12 (-3.80) SF15 (-1.56) SF17 (-0.59) SF18 (-5.29) SF21 (0.40) SF22 (2.78) SF23 (0.07) SF32 (-0.84) SF34 (0.00) SF35 (-3.68) SF3 (-2.47) SF30 (-4.38) HK2 (-2.10) HK23 (-2.91) HK41 (-0.03) SF4 (-0.55) SF8 (-2.06) SF9 (-6.85)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).