OncoDB.HCC Expression View

Gene name : PEG10
Ensembl ID ENSG00000198872
Description paternally expressed 10 isoform RF1/2 [Source:RefSeq_peptide;Acc:NP_055883]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
69 percent with 2 folds change ( 35 up and 4 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 7 from 89123794 bp to 99136940 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 193892 -- IMAGE clone locate on exon ( tblastx )
897678 -- IMAGE clone locate on exon ( tblastx )
2067059 -- IMAGE clone locate on exon ( tblastx )
CH2 (8.40) HK1 (8.63) HK3 (-0.43) HK4 (4.20) HK5 (0.85) HK7 (0.95) HK9 (0.00) HK11 (2.12) HK12 (3.02) HK13 (0.23) HK14 (5.62) HK15 (-0.09) HK16 (1.95) HK18 (8.50) HK19 (8.38) HK20 (4.13) HK21 (0.72) HK22 (0.46) HK24 (4.74) HK27 (2.47) HK28 (1.85) HK29 (4.72) HK31 (0.12) HK33 (0.20) HK36 (2.99) HK37 (3.40) HK38 (-1.26) HK39 (2.71) HK42 (3.08) HK46 (2.64) HK47 (2.20) HK49 (1.31) HK62 (1.98) HK63 (4.23) HK64 (1.70) HK67 (3.91) HK84 (0.99) HK85 (-0.48) SF1 (3.31) SF12 (3.30) SF15 (-3.24) SF17 (-0.13) SF18 (-0.68) SF21 (1.37) SF22 (-5.64) SF23 (-0.55) SF32 (2.49) SF34 (2.13) SF35 (1.49) SF3 (-2.96) SF30 (2.20) HK2 (0.27) HK23 (9.56) HK41 (-0.44) SF4 (1.18) SF8 (-0.16) SF9 (3.17)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).